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Developmental biology

Cell cycle unleashed

How does fertilization cause animal eggs to begin embryonic development? Following entry of the sperm, the ingeniously regulated degradation of a protein seems to kick-start the stalled cell cycle.

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Figure 1: Releasing the brakes.

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Kishimoto, T. Cell cycle unleashed. Nature 437, 963–965 (2005). https://doi.org/10.1038/437963a

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