Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Synthetic chemistry

Glycosylation with a twist

Nature has a whole battery of dedicated enzymes to make the complex links between sugar rings — how can synthetic chemists compete? An ingenious approach fills a big gap in the synthetic tool-kit.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Configurations of glycosidic bonds using glucose as an example.
Figure 2: Sugar twist.


  1. Kim, J. -H., Yang, H., Park, J. & Boons, G. -J. J. Am. Chem. Soc. doi:10.1021/ja052548h (2005).

  2. Douglas, N. L. et al. J. Chem. Soc. Perkin Trans. 51–66 (1998).

  3. Koeller, K. M. & Wong, C. -H. Chem. Rev. 100 4465–4493 (2000).

    CAS  Article  Google Scholar 

  4. Seeberger, P. H. Chem. Commun. 1115–1121 (2003).

  5. Fairbanks, A. J. Synlett 1945–1958 (2003).

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Flitsch, S. Glycosylation with a twist. Nature 437, 201–202 (2005).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing