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Synthetic chemistry

Glycosylation with a twist

Nature has a whole battery of dedicated enzymes to make the complex links between sugar rings — how can synthetic chemists compete? An ingenious approach fills a big gap in the synthetic tool-kit.

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Figure 1: Configurations of glycosidic bonds using glucose as an example.
Figure 2: Sugar twist.

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Flitsch, S. Glycosylation with a twist. Nature 437, 201–202 (2005). https://doi.org/10.1038/437201a

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