When proteins assemble themselves into fibres, there can be grave pathological consequences. Designing an otherwise soluble protein to make fibres provides a general mechanism for the construction process.
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Miranker, A. Fibres hinge on swapped domains. Nature 437, 197–198 (2005). https://doi.org/10.1038/437197a
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DOI: https://doi.org/10.1038/437197a
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