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Cell biology

Helices sculpt membrane

Many proteins are carried within cells in bubble-like sacs. These are pinched off from membranes inside the cell, and it seems that the Sar1p protein is key in both starting and finishing this budding process.

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Figure 1: Sar1p in budding and fission.


  1. McMahon, H. T. & Mills, I. G. Curr. Opin. Cell Biol. 16, 379–391 (2004).

    Article  CAS  Google Scholar 

  2. Lee, M. C. S. et al. Cell 122, 605–617 (2005).

    Article  CAS  Google Scholar 

  3. Matsuoka, K. et al. Cell 93, 263–275 (1998).

    Article  CAS  Google Scholar 

  4. Hristova, K. et al. J. Mol. Biol. 290, 99–117 (1999).

    Article  CAS  Google Scholar 

  5. Bi, X. et al. Nature 419, 271–277 (2002).

    Article  CAS  ADS  Google Scholar 

  6. Ford, M. G. et al. Nature 419, 361–366 (2002).

    Article  CAS  ADS  Google Scholar 

  7. Segrest, J. P. et al. J. Lipid Res. 33, 141–166 (1992).

    CAS  PubMed  Google Scholar 

  8. Bigay, J., Casella, J. F., Drin, G., Mesmin, B. & Antonny, B. EMBO J. 24, 2244–2253 (2005).

    Article  CAS  Google Scholar 

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Drin, G., Antonny, B. Helices sculpt membrane. Nature 437, 1247–1248 (2005).

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