Phytochemistry

Ibuprofen-like activity in extra-virgin olive oil

Enzymes in an inflammation pathway are inhibited by oleocanthal, a component of olive oil.

Abstract

Newly pressed extra-virgin olive oil contains oleocanthal — a compound whose pungency induces a strong stinging sensation in the throat, not unlike that caused by solutions of the non-steroidal anti-inflammatory drug ibuprofen1. We show here that this similar perception seems to be an indicator of a shared pharmacological activity, with oleocanthal acting as a natural anti-inflammatory compound that has a potency and profile strikingly similar to that of ibuprofen. Although structurally dissimilar, both these molecules inhibit the same cyclooxygenase enzymes in the prostaglandin-biosynthesis pathway.

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Figure 1: Structures of (−)oleocanthal (left) and the anti-inflammatory drug ibuprofen (right).

References

  1. 1

    Breslin, P. A. S., Gingerich, T. N. & Green, B. G. Chem. Sens. 26, 55–66 (2001).

    CAS  Article  Google Scholar 

  2. 2

    Andrewes, P., Busch, J. L. H. C., De Joode, T., Groenewegen, A. & Alexandre, H. J. Agric. Food Chem. 51, 1415–1420 (2003).

    CAS  Article  Google Scholar 

  3. 3

    Fischer, R., Griffen, F., Archer, R. C., Zinsmeister, S. C. & Jastram, P. S. Nature 207, 1049–1053 (1965).

    ADS  CAS  Article  Google Scholar 

  4. 4

    Vane, J. R. & Botting, R. M. Inflamm. Res. 44, 1–10 (1995).

    CAS  Article  Google Scholar 

  5. 5

    Harris, R. E., Beebe-Donk, J., Doss, H. & Burr Doss, D. Oncol. Rep. 13, 559–583 (2005).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. 6

    Zhou, Y. et al. Science 302, 1215–1217 (2003).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Hu, F. N. Engl. J. Med. 348, 2595–2596 (2003).

    Article  Google Scholar 

  8. 8

    Tuck, K., Freeman, M., Hayball, P., Stretch, G. & Stupans, I. J. Nutr. 131, 1993–1996 (2001).

    CAS  Article  Google Scholar 

  9. 9

    Miro-Casas, E. et al. Clin. Chem. 49, 945–952 (2003).

    CAS  Article  Google Scholar 

  10. 10

    Hennekens, C. H. Am. J. Man. Care 8 (suppl.), 691–700 (2002).

    Google Scholar 

  11. 11

    Lefer, A. M., Muller, H. F. & Smith, J. B. Br. J. Pharmacol. 83, 125–130 (1984).

    CAS  Article  Google Scholar 

  12. 12

    Togna, G. I., Togna, A. R., Franconi, M., Marra, C. & Guiso, M. J. Nutr. 133, 2532–2536 (2003).

    CAS  Article  Google Scholar 

  13. 13

    Mitchell, J. A. et al. Proc. Natl Acad. Sci. USA 90, 11693–11697 (1993).

    ADS  CAS  Article  Google Scholar 

Download references

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Correspondence to Paul A. S. Breslin.

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Beauchamp, G., Keast, R., Morel, D. et al. Ibuprofen-like activity in extra-virgin olive oil. Nature 437, 45–46 (2005). https://doi.org/10.1038/437045a

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