Synthetic biologists face up to security issues

Do technological advances need new rules?

Washington DC

Concerns about safety and security in the young field of synthetic biology are developing almost as rapidly as the research itself.

With scientists now able to create complete genomes from scratch and to introduce new characteristics into viruses and bacteria, there are fears that accidental — or worse, intentional — release of such creatures could occur.

As a result, the US government, academics and the field's first private companies are now working together to address the potential problems before they become a reality.

Synthetic biology is one of the priorities for the newly formed US National Science Advisory Board for Biosecurity (NSABB), which met for the first time in June. A working group on the topic, set up by the board, will begin its discussions later this month. Its members have already consulted synthetic biologists who have set up their own governance project, funded by the Alfred P. Sloan Foundation in New York, which will have its first meeting in September.

And one of the first public discussions of the issue comes this week, at a synthetic-biology meeting in San Francisco on 19–20 August. As well as looking at the field's potential in areas such as drug development, cellular reprogramming and biological robotics, participants will tackle ethical and legal issues.

The discussion will echo an event in 1975, when pioneers of genetic engineering retreated to the Asilomar Conference Center in California to set safety and ethical principles to guide their field. The fear was that modified microorganisms might escape into the environment with unpredictable effects, perhaps causing disease or out-competing wild strains.

Now synthetic biologists have much more powerful techniques at their disposal. Improved DNA synthesis means, for example, that microbial genomes can be built from scratch, bypassing the need to get hold of the actual organism. A dramatic demonstration of the potential consequences came in July 2002, when researchers at the University of New York at Stony Brook reported that they had synthesized an infectious poliovirus using mail-order DNA (see Nature 418, 265; 200210.1038/418265a). Genome sequencer Craig Venter followed that by announcing plans to build a bacterium from lab synthesized DNA and by taking just three weeks to synthesize a virus that infects bacteria (H. O. Smith et al. Proc. Natl Acad. Sci. USA 100, 15440–15445; 2003).

Others are using made-to-order components to re-engineer the genomes of bacteria or viruses — either to investigate how they work or to try to give them abilities that they would not have naturally, such as producing drug molecules or generating hydrogen for use as an energy source. In theory, these techniques could be used to create deadly organisms in the lab, such as Ebola or anthrax, or to make bacteria more dangerous by giving them antibiotic resistance, for example, or the ability to make additional toxins.

Does this increased sophistication mean that the field needs radically new rules? Drew Endy, a synthetic biologist at Massachusetts Institute of Technology and one of the leaders of the Sloan Foundation project, is not sure. “There hasn't been a clear conversation about whether de novo synthesis poses a different threat from genetic engineering,” he says.

Wendell Lim at the University of California, San Francisco, who uses synthetic biology to study basic processes such as how cells grow and move, says that there is nothing special about the field that requires blanket restrictions and that each type of study should be judged on its own risks and merits. “To broadly raise alarms about all such approaches is akin to saying we should worry about all uses of semiconductors because one of their uses could be in launch systems for nuclear weapons,” he says. “We need to distinguish the sub-areas of the field and specific biological components that truly pose a hazard, and figure out how to regulate them.”

Taking care

But there are some general precautions that most synthetic biologists support. Many think it would make sense to monitor products ordered from companies that generate synthetic genes on demand, such as Codon Devices in Cambridge, Massachusetts, and Blue Heron Biotechnology in Bothell, Washington.

The ability to build genomes in the lab has raised fears that the technology could be abused. Credit: S. OGDEN/SPL

George Church, who co-founded Codon Devices this spring, wants to go further, arguing that strict regulation is a key to heading off the public-relations problems that have plagued other areas of biotechnology. As well as monitoring orders for components such as synthetic genes, he says the government should screen certain raw materials that scientists could use to brew up their own DNA. “Basically you want a series of licences to cover almost every step where there's a reasonable bottleneck you can regulate,” he says.

But many argue that the openness of the field offers a built-in safety mechanism against unintentionally creating something harmful. For instance, Endy's lab hosts an online library of parts that can be built into genomes. The library is open source, meaning that all scientists in the field can test them. “There's an element of safety in using well characterized components,” says Christopher Voigt, a synthetic biologist at the University of California, San Francisco.

Other synthetic biologists point out the success of initiatives to encourage young scientists to think about safety and ethical issues relating to their work. “It's important to talk about ways to minimize risk, and one of the most important ways to do that is to train responsible scientists and engineers,” says Christina Smolke, a chemical engineer at the California Institute of Technology in Pasadena.

So far, observers are giving synthetic biologists credit for tackling such issues. But some, such as Paul Rabinow, an anthropologist at the University of California, Berkeley, think that the field needs to take a broader view than it has so far. He is speaking at the San Francisco meeting this week and says he will tell attendees to pay more attention to the danger that synthetic biology could be abused for biowarfare or bioterrorism, something that is harder to control than the risk of accidents.

“The field has been attempting to turn this into a safety issue, but we're living today in a security regime,” he told Nature. “Dealing with safety is good, but they're fooling themselves if they think that's going to be the end of this question.”

Venter agrees, arguing that rather than regulating labs and companies, governments need to use synthetic biology to develop ways to defeat bioterrorist attacks, such as producing drugs and vaccines, or sensors to detect altered organisms in the environment. “If we're not concentrating 100% of our defensive effort on countermeasures, I think we're missing the big picture,” he told the NSABB in June.


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Synthetic biology: Starting from scratch

Futures of artificial life

Poliovirus advance sparks fears of data curbs

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Life engineering symposium

Registry of standard biological parts

Church lab

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Check, E. Synthetic biologists face up to security issues. Nature 436, 894–895 (2005).

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