Tumour biology

Senescence in premalignant tumours

Article metrics

Abstract

Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development1,2, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Premalignant lung adenomas induced by oncogenic K-ras are positive for markers of senescence, whereas malignant adenocarcinomas are negative.

References

  1. 1

    Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. & Lowe, S. W. Cell 88, 593–602 (1997).

  2. 2

    Lowe, S. W., Cepero, E. & Evan, G. Nature 432, 307–315 (2004).

  3. 3

    Guerra, C. et al. Cancer Cell 4, 111–120 (2003).

  4. 4

    Dimri, G. P. et al. Proc. Natl Acad. Sci. USA 92, 9363–9367 (1995).

  5. 5

    Narita, M. et al. Cell 113, 703–716 (2003).

  6. 6

    Palmero, I., Pantoja, C. & Serrano, M. Nature 395, 125–126 (1998).

  7. 7

    Tuveson, D. A. et al. Cancer Cell 5, 375–387 (2004).

Download references

Author information

Correspondence to Manuel Serrano.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Rights and permissions

Reprints and Permissions

About this article

Further reading

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.