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Cancer

Crime and punishment

Cellular senescence stops the growth of cells. This process, first glimpsed in cell culture, is now confirmed by in vivo evidence as a vital mechanism that constrains the malignant progression of many tumours.

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Figure 1: A senescence wiring diagram.

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Sharpless, N., DePinho, R. Crime and punishment. Nature 436, 636–637 (2005). https://doi.org/10.1038/436636a

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