Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Metabolism

A is for adipokine

Adipokines are hormones that signal changes in fatty-tissue mass and energy status so as to control fuel usage. A fat-derived adipokine that binds to vitamin A provides a new link between obesity and insulin resistance.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Retinol binding protein-4 (RBP4) in glucose metabolism.

References

  1. Engelgau, M. M. et al. Ann. Intern. Med. 140, 945–950 (2004).

    Article  Google Scholar 

  2. Yang, Q. et al. Nature 436, 356–362 (2005).

    Article  ADS  CAS  Google Scholar 

  3. Halaas, J. L. et al. Science 269, 543–546 (1995).

    Article  ADS  CAS  Google Scholar 

  4. Mora, S. & Pessin, J. E. Diabetes Metab. Res. Rev. 18, 345–356 (2002).

    Article  CAS  Google Scholar 

  5. Kahn, B. B. J. Nutr. 124 1289S–1295S (1994).

    Article  CAS  Google Scholar 

  6. Tozzo, E., Shepherd, P. R., Gnudi, L. & Kahn, B. B. Am. J. Physiol. Endocrinol. Metab. 268, E956–E964 (1995).

    Article  CAS  Google Scholar 

  7. Gnudi, L., Shepherd, P. R. & Kahn, B. B. Proc. Nutr. Soc. 55, 191–199 (1996).

    Article  CAS  Google Scholar 

  8. Abel, E. D. et al. Nature 409, 729–733 (2001).

    Article  ADS  CAS  Google Scholar 

  9. Quadro, L., Hamberger, L., Colantuoni, V., Gottesman, M. E. & Blaner, W. S. Mol. Aspects Med. 24, 421–430 (2003).

    Article  CAS  Google Scholar 

  10. Marill, J., Idres, N., Capron, C. C., Nguyen, E. & Chabot, G. G. Curr. Drug Metab. 4, 1–10 (2003).

    Article  CAS  Google Scholar 

  11. Ferre, P. Diabetes 53 (Suppl. 1), S43–S50 (2004).

    Article  CAS  Google Scholar 

  12. McGarry, J. D. Diabetes 51, 7–18 (2002).

    Article  CAS  Google Scholar 

  13. Sivitz, W. I., Desautel, S. L., Kayano, T., Bell, G. I. & Pessin, J. E. Nature 340, 72–74 (1989).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Muoio, D., Newgard, C. A is for adipokine. Nature 436, 337–338 (2005). https://doi.org/10.1038/436337a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/436337a

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing