Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cancer biology

Sleeping Beauty awakens

Ancient jumping DNA found napping in fish has been revived and is being used to identify cancer genes in mice. But the benefits of this aptly named ‘Sleeping Beauty’ system could reach far beyond cancer.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type



Prices may be subject to local taxes which are calculated during checkout

Figure 1: DNA leaps out of fish and into cancer research.


  1. McClintock, B. Proc. Natl Acad. Sci. USA 36, 344–355 (1950).

    Article  ADS  CAS  Google Scholar 

  2. Ivics, Z., Hackett, P. B., Plasterk, R. H. & Izsvak, Z. Cell 91, 501–510 (1997).

    Article  CAS  Google Scholar 

  3. Dupuy, A. J., Akagi, K., Largaespada, D. A., Copeland, N. G. & Jenkins, N. A. Nature 436, 221–226 (2005).

    Article  ADS  CAS  Google Scholar 

  4. Collier, L. S., Carlson, C. M., Ravimohan, S., Dupuy, A. J. & Largaespada, D. A. Nature 436, 272–276 (2005).

    Article  ADS  CAS  Google Scholar 

  5. Brosius, J. Bioinformatics 19 (Suppl. 2), ii35 (2003).

    Google Scholar 

  6. Vogelstein, B. & Kinzler, K. W. Trends Genet. 9, 138–141 (1993).

    Article  CAS  Google Scholar 

  7. Suzuki, T. et al. Nature Genet. 32, 166–174 (2002).

    Article  CAS  Google Scholar 

  8. Hansen, G. M., Skapura, D. & Justice, M. J. Genome Res. 10, 237–243 (2000).

    Article  CAS  Google Scholar 

  9. Marx, J. Science 301, 1308–1310 (2003).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Weiser, K., Justice, M. Sleeping Beauty awakens. Nature 436, 184–185 (2005).

Download citation

  • Published:

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing