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Biological chemistry

Just add chlorine

Nature provides lessons about developing ‘green chemistry’ in seemingly out-of-the-way places. One such lesson comes from an enzymatic step in the production of a leaf toxin by a bacterium.

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Figure 1: Chlorine in natural-product synthesis.
Figure 2: Chlorinating unreactive organic compounds.

References

  1. Vaillancourt, F. H., Yeh, E., Vosburg, D. A., O'Connor, S. E. & Walsh, C. T. Nature 436, 1191–1194 (2005).

    ADS  CAS  Article  Google Scholar 

  2. Hausinger, R. P. Crit. Rev. Biochem. Mol. Biol. 39, 21–68 (2004).

    CAS  Article  Google Scholar 

  3. Yeh, E., Garneau, S. & Walsh, C. T. Proc. Natl Acad. Sci. USA 102, 3960–3965 (2005).

    ADS  CAS  Article  Google Scholar 

  4. Vaillancourt, F. H., Yin, J. & Walsh, C. T. Proc. Natl Acad. Sci. USA 102, 10111–10116 (2005).

    ADS  CAS  Article  Google Scholar 

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Schnarr, N., Khosla, C. Just add chlorine. Nature 436, 1094–1095 (2005). https://doi.org/10.1038/4361094a

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