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Genome evolution

Global methylation in eutherian hybrids


O'Neill et al. propose that epigenetic pro-cesses help to drive karyotypic evolution in marsupials1. Here we present evidence that global methylation patterns do not undergo dramatic changes in interspecific hybrids among three orders of placental mammals, indicating that the mechanisms underlying genome evolution may be different in placental mammals and marsupials.

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Figure 1: Genome methylation analysis in interspecific hybrids by HpaII (left lanes) and MspI (right lanes) digestion.
Figure 2: Methylation analysis of M. musculus Cremona×M. spretus chromosomes.


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Correspondence to Reinald Fundele.

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Roemer, I., Grützner, F., Winking, H. et al. Global methylation in eutherian hybrids. Nature 401, 131–132 (1999).

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