O'Neill et al. propose that epigenetic pro-cesses help to drive karyotypic evolution in marsupials1. Here we present evidence that global methylation patterns do not undergo dramatic changes in interspecific hybrids among three orders of placental mammals, indicating that the mechanisms underlying genome evolution may be different in placental mammals and marsupials.
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O'Neill, R. J. W., O'Neill, M. J. & Graves, J. A. M. Nature 393, 68–72 (1998).
Gray, A. P. in Mammalian Hybrids (Commonwealth Agricultural Bureau, Edinburgh, 1971).
Allen, W. R., Skidmore, J. A., Stewart, F. & Antczak, D. F. J. Reprod. Fertil. 9, 55–60 (1993).
Rogers, J. F. & Dawson, W. D. J. Reprod. Fertil. 21, 255–262 (1970).
Zechner, U. et al. Nature Genet. 12, 398–403 (1996).
Orr, H. A. Annu. Rev. Ecol. Syst. 28, 195–218 (1997).
Templeton, A. R. Annu. Rev. Ecol. Syst. 12, 23–48 (1981).
Smith, M. J., Hayman, D. L. & Hope, R. M. Aust. J. Zool. 27, 959–972 (1979).
Graves, J. A. M. Trends Genet. 3, 252–256 (1987).
Migeon, B. R. Trends Genet .10, 415–417 (1994).
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Roemer, I., Grützner, F., Winking, H. et al. Global methylation in eutherian hybrids. Nature 401, 131–132 (1999). https://doi.org/10.1038/43607
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