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Genome evolution

Global methylation in eutherian hybrids

Nature volume 401, pages 131–132 (1999)Cite this article

Abstract

O'Neill et al. propose that epigenetic pro-cesses help to drive karyotypic evolution in marsupials1. Here we present evidence that global methylation patterns do not undergo dramatic changes in interspecific hybrids among three orders of placental mammals, indicating that the mechanisms underlying genome evolution may be different in placental mammals and marsupials.

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Figure 1: Genome methylation analysis in interspecific hybrids by HpaII (left lanes) and MspI (right lanes) digestion.
Figure 2: Methylation analysis of M. musculus Cremona×M. spretus chromosomes.

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Author information

Authors and Affiliations

  1. Max-Planck-Institut für Molekulare Genetik, Ihnestrasse 73, Berlin, 14195, Germany

    Irmgard Roemer, Frank Grützner, Thomas Haaf & Reinald Fundele

  2. Institut für Biologie, Medizinische Universität Lübeck, Lübeck, 23562, Germany

    Heinz Winking

  3. Laboratoire Génome et Populations, Université de Montpellier II, Montpellier, 34095, France

    Annie Orth

  4. Camel Reproduction Centre, Dubai, United Arab Emirates

    Lulu Skidmore

  5. James A. Baker Institute for Animal Health, College of Veterinary Medicine, Cornell University, Ithaca, 14853, New York, USA

    Doug Antczak

Authors
  1. Irmgard Roemer
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  2. Frank Grützner
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  3. Heinz Winking
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  4. Thomas Haaf
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  5. Annie Orth
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  6. Lulu Skidmore
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  7. Doug Antczak
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  8. Reinald Fundele
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Correspondence to Reinald Fundele.

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Roemer, I., Grützner, F., Winking, H. et al. Global methylation in eutherian hybrids. Nature 401, 131–132 (1999). https://doi.org/10.1038/43607

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