Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Genome evolution

Global methylation in eutherian hybrids

Abstract

O'Neill et al. propose that epigenetic pro-cesses help to drive karyotypic evolution in marsupials1. Here we present evidence that global methylation patterns do not undergo dramatic changes in interspecific hybrids among three orders of placental mammals, indicating that the mechanisms underlying genome evolution may be different in placental mammals and marsupials.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Genome methylation analysis in interspecific hybrids by HpaII (left lanes) and MspI (right lanes) digestion.
Figure 2: Methylation analysis of M. musculus Cremona×M. spretus chromosomes.

Similar content being viewed by others

References

  1. O'Neill, R. J. W., O'Neill, M. J. & Graves, J. A. M. Nature 393, 68–72 (1998).

    Article  ADS  CAS  PubMed  Google Scholar 

  2. Gray, A. P. in Mammalian Hybrids (Commonwealth Agricultural Bureau, Edinburgh, 1971).

  3. Allen, W. R., Skidmore, J. A., Stewart, F. & Antczak, D. F. J. Reprod. Fertil. 9, 55–60 (1993).

    Article  Google Scholar 

  4. Rogers, J. F. & Dawson, W. D. J. Reprod. Fertil. 21, 255–262 (1970).

    Article  CAS  PubMed  Google Scholar 

  5. Zechner, U. et al. Nature Genet. 12, 398–403 (1996).

    Article  CAS  PubMed  Google Scholar 

  6. Orr, H. A. Annu. Rev. Ecol. Syst. 28, 195–218 (1997).

    Article  Google Scholar 

  7. Templeton, A. R. Annu. Rev. Ecol. Syst. 12, 23–48 (1981).

    Article  Google Scholar 

  8. Smith, M. J., Hayman, D. L. & Hope, R. M. Aust. J. Zool. 27, 959–972 (1979).

    Article  Google Scholar 

  9. Graves, J. A. M. Trends Genet. 3, 252–256 (1987).

    Article  Google Scholar 

  10. Migeon, B. R. Trends Genet .10, 415–417 (1994).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Reinald Fundele.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Roemer, I., Grützner, F., Winking, H. et al. Global methylation in eutherian hybrids. Nature 401, 131–132 (1999). https://doi.org/10.1038/43607

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/43607

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing