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Cell biology

Sterol sensor comes up for air

In one example of a feedback mechanism in mammals, cells switch cholesterol synthesis on or off depending on the availability of sterol. A rewired version of this pathway in yeast acts instead as an oxygen sensor.

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Figure 1: New tricks for a familiar pathway.


  1. Hughes, A. L., Todd, B. L. & Espenshade, P. J. Cell 120, 831–842 (2005).

    Article  CAS  Google Scholar 

  2. Horton, J. D., Goldstein, J. L. & Brown, M. S. Cold Spring Harb. Symp. Quant. Biol. 67, 491–498 (2002).

    Article  CAS  Google Scholar 

  3. Shearer, A. G. & Hampton, R. Y. EMBO J. 24, 149–159 (2005).

    Article  CAS  Google Scholar 

  4. Song, B. -L., Javitt, N. B. & DeBose-Boyd, R. A. Cell Metabolism 1, 179–189 (2005).

    Article  CAS  Google Scholar 

  5. Dobrosotskaya, I. Y., Seegmiller, A. C., Brown, M. S., Goldstein, J. L. & Rawson, R. B. Science 296, 879–883 (2002).

    Article  ADS  CAS  Google Scholar 

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Garza, R., Hampton, R. Sterol sensor comes up for air. Nature 435, 37–38 (2005).

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