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Cell biology

Sterol sensor comes up for air

In one example of a feedback mechanism in mammals, cells switch cholesterol synthesis on or off depending on the availability of sterol. A rewired version of this pathway in yeast acts instead as an oxygen sensor.

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Figure 1: New tricks for a familiar pathway.

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Garza, R., Hampton, R. Sterol sensor comes up for air. Nature 435, 37–38 (2005). https://doi.org/10.1038/435037a

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