Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cell biology

Sterol sensor comes up for air

Nature volume 435, pages 37–38 (2005)Cite this article

In one example of a feedback mechanism in mammals, cells switch cholesterol synthesis on or off depending on the availability of sterol. A rewired version of this pathway in yeast acts instead as an oxygen sensor.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: New tricks for a familiar pathway.

References

  1. Hughes, A. L., Todd, B. L. & Espenshade, P. J. Cell 120, 831–842 (2005).

    Article  CAS  Google Scholar 

  2. Horton, J. D., Goldstein, J. L. & Brown, M. S. Cold Spring Harb. Symp. Quant. Biol. 67, 491–498 (2002).

    Article  CAS  Google Scholar 

  3. Shearer, A. G. & Hampton, R. Y. EMBO J. 24, 149–159 (2005).

    Article  CAS  Google Scholar 

  4. Song, B. -L., Javitt, N. B. & DeBose-Boyd, R. A. Cell Metabolism 1, 179–189 (2005).

    Article  CAS  Google Scholar 

  5. Dobrosotskaya, I. Y., Seegmiller, A. C., Brown, M. S., Goldstein, J. L. & Rawson, R. B. Science 296, 879–883 (2002).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. the Division of Biological Sciences, Section of Cell and Developmental Biology, University of California at San Diego, La Jolla, 92093-0347, California, USA

    Renee M. Garza & Randolph Y. Hampton

Authors
  1. Renee M. Garza
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Randolph Y. Hampton
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Garza, R., Hampton, R. Sterol sensor comes up for air. Nature 435, 37–38 (2005). https://doi.org/10.1038/435037a

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/435037a

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing