Glucose output from the liver is tightly regulated by insulin. But insulin holds sway over more than the liver — an unappreciated circuit in glucose control involves the opening of ion channels in the brain.
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Gribble, F. A higher power for insulin. Nature 434, 965–966 (2005). https://doi.org/10.1038/434965a
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DOI: https://doi.org/10.1038/434965a
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