Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:


A pore way to die

Like Jekyll to Hyde, mitochondria can change from acting as the cell's powerhouses to become merciless killers. Mice lacking this mechanism develop normally, and their hearts are resistant to pathological damage.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A killing machine.


  1. Green, D. & Kroemer, G. Science 305, 626–629 (2004).

    Article  ADS  CAS  Google Scholar 

  2. Nakagawa, T. et al. Nature 434, 652–658 (2005).

    Article  ADS  CAS  Google Scholar 

  3. Baines, C. P. et al. Nature 434, 658–662 (2005).

    Article  ADS  CAS  Google Scholar 

  4. Halestrap, A. P., Clarke, S. J. & Javadov, S. A. Cardiovasc. Res. 61, 372–385 (2004).

    Article  CAS  Google Scholar 

  5. Halestrap, A. P., McStay, G. P. & Clarke, S. J. Biochimie 84, 153–166 (2002).

    Article  CAS  Google Scholar 

  6. Bernardi, P., Petronilli, V., DiLisa, F. & Forte, M. Trends Biochem. Sci. 26, 112–117 (2001).

    Article  CAS  Google Scholar 

  7. Waldmeier, P. C. et al. Curr. Med. Chem. 10, 1485–1506 (2003).

    Article  CAS  Google Scholar 

  8. Kokoszka, J. E. et al. Nature 427, 461–465 (2004).

    Article  ADS  CAS  Google Scholar 

  9. Halestrap, A. P. Nature doi:10.1038/nature02816 (2004).

  10. Crompton, M., Ellinger, H. & Costi, A. Biochem. J. 255, 357–360 (1988).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Henry-Mowatt, J., Dive, C., Martinou, J. C. & James, D. Oncogene 23, 2850–2860 (2004).

    Article  CAS  Google Scholar 

  12. Li, Y. M., Johnson, N., Capano, M., Edwards, M. & Crompton, M. Biochem. J. 383, 101–109 (2004).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Halestrap, A. A pore way to die. Nature 434, 578–579 (2005).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing