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Viral blitzkrieg

It takes years for AIDS to develop from the damage inflicted on the immune system by HIV or its simian counterpart. Surprisingly, as many as half of the body's memory T cells may die at a very early stage of infection.

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Figure 1: Model for the depletion of gut CD4-expressing T lymphocytes by SIV.


  1. Mattapallil, J. J. et al. Nature 434, 1093–1097 (2005).

    ADS  CAS  Article  Google Scholar 

  2. Li, Q. et al. Nature 434, 1148–1152 (2005).

    ADS  CAS  Article  Google Scholar 

  3. Haase, A. T. Annu. Rev. Immunol. 17, 625–656 (1999).

    CAS  Article  Google Scholar 

  4. Veazey, R. S. et al. Science 280, 427–431 (1998).

    ADS  CAS  Article  Google Scholar 

  5. Brenchley, J. M. et al. J. Exp. Med. 200, 749–759 (2004).

    CAS  Article  Google Scholar 

  6. Mehandru, S. et al. J. Exp. Med. 200, 761–770 (2004).

    CAS  Article  Google Scholar 

  7. Zhang, Z. et al. Science 286, 1353–1357 (1999).

    CAS  Article  Google Scholar 

  8. Picker, L. J. et al. J. Exp. Med. 200, 1299–1314 (2004).

    CAS  Article  Google Scholar 

  9. Unutmaz, D., KewalRamano, V. N., Marmon, S. & Littman, D. R. J. Exp. Med. 189, 1735–1746 (1999).

    CAS  Article  Google Scholar 

  10. Chiu, Y. -L. et al. Nature doi:10.1038/nature03493 (2005).

  11. Robinson, H. L. Nature Rev. Immunol. 2, 239–250 (2002).

    CAS  Article  Google Scholar 

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Johnson, R., Kaur, A. Viral blitzkrieg. Nature 434, 1080–1081 (2005).

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