In the Northern Hemisphere, large-scale glaciation was initiated comparatively recently. Paradoxically, it seems that the trigger was a seasonal warming of the sea surface in an upwind oceanic region.
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Billups, K. Snow maker for the ice ages. Nature 433, 809–810 (2005). https://doi.org/10.1038/433809a
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DOI: https://doi.org/10.1038/433809a