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Fertility hormone in repose

Egg and sperm development are triggered when follicle-stimulating hormone binds to its receptor. A three-dimensional structural snapshot reveals how the hormone slots into its receptor, and how specificity of binding is ensured.

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Figure 1: Hormones and receptors: keys and locks.


  1. Wright, V. C., Schieve, L. A., Reynolds, M. A., Jeng, G. & Kissin, D. MMWR Surveill. Summ. 53, 1–20 (2004).

    PubMed  Google Scholar 

  2. Fan, Q. R. & Hendrickson, W. A. Nature 433, 269–277 (2005).

    ADS  CAS  Article  Google Scholar 

  3. Kobe, B. & Kajava, A. V. Curr. Opin. Struct. Biol. 11, 725–732 (2001).

    CAS  Article  Google Scholar 

  4. Hopkins, A. L. & Groom, C. R. Nature Rev. Drug Discov. 1, 727–730 (2002).

    CAS  Article  Google Scholar 

  5. Dias, J. A. et al. in Vitamins and Hormones (ed. Litwack, G.) 249–322 (Academic, New York, 2002).

    Book  Google Scholar 

  6. Smits, G. et al. N. Engl. J. Med. 349, 760–766 (2003).

    CAS  Article  Google Scholar 

  7. Vasseur, C. et al. N. Engl. J. Med. 349, 753–759 (2003).

    CAS  Article  Google Scholar 

  8. Lapthorn, A. J. et al. Nature 369, 455–461 (1994).

    ADS  CAS  Article  Google Scholar 

  9. Wu, H., Lustbader, J. W., Liu, Y., Canfield, R. E. & Hendrickson, W. A. Structure 2, 545–558 (1994).

    CAS  Article  Google Scholar 

  10. Fox, K. M., Dias, J. A. & Van Roey, P. Mol. Endocrinol. 15, 378–389 (2001).

    CAS  Article  Google Scholar 

  11. Palczewski, K. et al. Science 289, 739–745 (2000).

    ADS  CAS  Article  Google Scholar 

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Dias, J. Fertility hormone in repose. Nature 433, 203–204 (2005).

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