Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Human immunodeficiency virus

Nuclear RNA export unwound

The ways in which HIV can subvert cellular processes for its own ends seem boundless. The latest discovery — a cellular enzyme that helps to export HIV RNA from the nucleus — reveals a possible drug target.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Escape from the nucleus: how cellular and HIV-1 messenger RNAs are exported.


  1. Cullen, B. R. J. Cell Sci. 116, 587–597 (2003).

    Article  Google Scholar 

  2. Dreyfuss, G., Kim, V. N. & Kataoka, N. Nature Rev. Mol. Cell Biol. 3, 195–205 (2002).

    Article  CAS  Google Scholar 

  3. Snay-Hodge, C. A., Colot, H. V., Goldstein, A. L. & Cole, C. N. EMBO J. 17, 2663–2676 (1998).

    Article  CAS  Google Scholar 

  4. Tseng, S. S. -I. et al. EMBO J. 17, 2651–2662 (1998).

    Article  CAS  Google Scholar 

  5. Schmitt, C. et al. EMBO J. 18, 4332–4347 (1999).

    Article  CAS  Google Scholar 

  6. Yedavalli, V. S. R. K., Neuveut, C., Chi, Y. -h., Kleiman, L. & Jeang, K. -T. Cell 119, 381–392 (2004).

    Article  CAS  Google Scholar 

  7. Rocak, S. & Linder, P. Nature Rev. Mol. Cell Biol. 5, 232–241 (2004).

    Article  CAS  Google Scholar 

  8. Schwer, B. Nature Struct. Biol. 8, 113–116 (2001).

    Article  CAS  Google Scholar 

  9. Zhao, J., Jin, S. -B., Björkroth, B., Wieslander, L. & Daneholt, B. EMBO J. 21, 1177–1187 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and permissions

About this article

Cite this article

Cullen, B. Nuclear RNA export unwound. Nature 433, 26–27 (2005).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing