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Cell biology

Adhesion articulated

A new structure of the ‘head’ region of an integrin protein explains the remarkable vertical extension that enables these molecules to rise to the task of mediating cell adhesion.

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Figure 1: Integrin activation states.
Figure 2: The complex between a macromolecular ligand and the integrin head domains.

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Mould, A., Humphries, M. Adhesion articulated. Nature 432, 27–28 (2004). https://doi.org/10.1038/432027a

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