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Cell biology

Sight at the end of the tunnel

A chaperone molecule called trigger factor binds new polypeptide chains as they emerge from the protein-synthesis machinery. Crystal structures suggest that this molecule forms a hydrophobic ‘cradle’.

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Figure 1: Chaperones at the ribosome.


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Horwich, A. Sight at the end of the tunnel. Nature 431, 520–522 (2004).

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