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Molecular biology

Genetic code seizes pyrrolysine

Identification of the enzyme that mediates insertion of a rare amino acid, pyrrolysine, into protein solves a puzzle and expands the rules of the genetic code established nearly half a century ago.

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Figure 1: RNA structures signal incorporation of non-canonical amino acids.

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Schimmel, P., Beebe, K. Genetic code seizes pyrrolysine. Nature 431, 257–258 (2004). https://doi.org/10.1038/431257a

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