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Immunology

Aid for AID

Activation-induced deaminase catalyses two processes that diversify antibodies. But this enzyme need not work alone: a partner links it to its substrate — single-stranded DNA — and to DNA-repair molecules.

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Figure 1: Generating antibody diversity.

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Ramiro, A., Nussenzweig, M. Aid for AID. Nature 430, 980–981 (2004). https://doi.org/10.1038/430980b

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