Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Immunology

Aid for AID

Activation-induced deaminase catalyses two processes that diversify antibodies. But this enzyme need not work alone: a partner links it to its substrate — single-stranded DNA — and to DNA-repair molecules.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Generating antibody diversity.

References

  1. Muramatsu, M. et al. Cell 102, 553–563 (2000).

    Article  CAS  Google Scholar 

  2. Revy, P. et al. Cell 102, 565–575 (2000).

    Article  CAS  Google Scholar 

  3. Chaudhuri, J., Khuong, C. & Alt, F. W. Nature 430, 992–998 (2004).

    Article  ADS  CAS  Google Scholar 

  4. Petersen-Mahrt, S. K., Harris, R. S. & Neuberger, M. S. Nature 418, 99–103 (2002).

    Article  ADS  CAS  Google Scholar 

  5. Chaudhuri, J. et al. Nature 422, 726–730 (2003).

    Article  ADS  CAS  Google Scholar 

  6. Bransteitter, R., Pham, P., Scharff, M. D. & Goodman, M. F. Proc. Natl Acad. Sci. USA 100, 4102–4107 (2003).

    Article  ADS  CAS  Google Scholar 

  7. Dickerson, S. K., Market, E., Besmer, E. & Papavasiliou, F. N. J. Exp. Med. 197, 1291–1296 (2003).

    Article  CAS  Google Scholar 

  8. Pham, P., Bransteitter, R., Petruska, J. & Goodman, M. F. Nature 424, 103–107 (2003).

    Article  ADS  CAS  Google Scholar 

  9. Ramiro, A. R. et al. Nature Immunol. 4, 452–456 (2003).

    Article  CAS  Google Scholar 

  10. Nambu, Y. et al. Science 302, 2137–2140 (2003).

    Article  ADS  CAS  Google Scholar 

  11. Di Noia, J. & Neuberger, M. S. Nature 419, 43–48 (2002).

    Article  ADS  CAS  Google Scholar 

  12. Imai, K. et al. Nature Immunol. 4, 1023–1028 (2003).

    Article  CAS  Google Scholar 

  13. Storb, U. & Stavnezer, J. Curr. Biol. 12, R725–R727 (2002).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Ramiro, A., Nussenzweig, M. Aid for AID. Nature 430, 980–981 (2004). https://doi.org/10.1038/430980b

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/430980b

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing