Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Structural biology

Anthrax hijacks host receptor

An atomic picture of how anthrax toxin binds to its host's cells reveals that the toxin commandeers a host receptor protein and tricks it into helping the toxin enter the cell.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Throwing the anthrax switch.

References

  1. 1

    Jefferds, M. D. et al. Emerg. Infect. Dis. 8, 1138–1144 (2002).

    Article  Google Scholar 

  2. 2

    Santelli, E., Bankston, L. A., Leppla, S. H. & Liddington, R. C. Nature 430, 905–908 (2004).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Wigelsworth, D. J. et al. J. Biol. Chem. 279, 23349–23356 (2004).

    CAS  Article  Google Scholar 

  4. 4

    Lacy, D. B. et al. Proc. Natl Acad. Sci. USA 101, 6367–6372 (2004).

    ADS  CAS  Article  Google Scholar 

  5. 5

    Emsley, J., Knight, C. G., Farndale, R. W., Barnes, M. J. & Liddington, R. C. Cell 101, 47–56 (2000).

    CAS  Article  Google Scholar 

  6. 6

    Petosa, C., Collier, R. J., Klimpel, K. R., Leppla, S. H. & Liddington, R. C. Nature 385, 833–838 (1997).

    ADS  CAS  Article  Google Scholar 

  7. 7

    Leppla, S. H. Proc. Natl Acad. Sci. USA 79, 3162–3166 (1982).

    ADS  CAS  Article  Google Scholar 

  8. 8

    Park, J. M., Greten, F. R., Li, Z. W. & Karin, M. Science 297, 2048–2051 (2002).

    ADS  CAS  Article  Google Scholar 

  9. 9

    Blaustein, R. O., Koehler, T. M., Collier, R. J. & Finkelstein, A. Proc. Natl Acad. Sci. USA 86, 2209–2213 (1989).

    ADS  CAS  Article  Google Scholar 

  10. 10

    Bell, S. E. et al. J. Cell Sci. 114, 2755–2773 (2001).

    ADS  CAS  PubMed  Google Scholar 

  11. 11

    Galdiero, S. & Gouaux, E. Protein Sci. 13, 1503–1511 (2004).

    CAS  Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bann, J., Hultgren, S. Anthrax hijacks host receptor. Nature 430, 843–844 (2004). https://doi.org/10.1038/430843a

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing