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Regenerative medicine

Self-help for insulin cells

Insulin-producing β-cells in the adult pancreas were thought to derive from pancreatic stem cells. But it seems that they arise abundantly from β-cells themselves, offering a new outlook on regenerative medicine.

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Figure 1: Where do adult β-cells come from?

References

  1. Shapiro, A. M. N. Engl. J. Med. 343, 230–238 (2000).

    Article  CAS  Google Scholar 

  2. Dor, Y., Brown, J., Martinez, O. I. & Melton, D. A. Nature 429, 41–46 (2004).

    Article  ADS  CAS  Google Scholar 

  3. Butler, A. E. et al. Diabetes 52, 102–110 (2003).

    Article  CAS  Google Scholar 

  4. Bonner-Weir, S., Baxter, L. A., Schuppin, G. T. & Smith, F. E. Diabetes 42, 1715–1720 (1993).

    Article  CAS  Google Scholar 

  5. Herrera, P. L. Development 127, 2317–2322 (2000).

    CAS  PubMed  Google Scholar 

  6. Rhim, J. A., Sandgren, E. P., Degen, J. L., Palmiter, R. D. & Brinster, R. L. Science 263, 1149–1152 (1994).

    Article  ADS  CAS  Google Scholar 

  7. Overturf, K., al-Dhalimy, M., Ou, C. N., Finegold, M. & Grompe, M. Am. J. Pathol. 151, 1273–1280 (1997).

    CAS  PubMed  PubMed Central  Google Scholar 

  8. Wang, R. N., Kloppel, G. & Bouwens, L. Diabetologia 38, 1405–1411 (1995).

    Article  CAS  Google Scholar 

  9. Tyrberg, B., Ustinov, J., Otonkoski, T. & Andersson, A. Diabetes 50, 301–307 (2001).

    Article  CAS  Google Scholar 

  10. Lammert, E., Cleaver, O. & Melton, D. Science 294, 564–567 (2001).

    Article  CAS  Google Scholar 

  11. Yoshitomi, H. & Zaret, K. S. Development 131, 807–817 (2004).

    Article  CAS  Google Scholar 

  12. Thomson, J. A. et al. Science 282, 1145–1147 (1998).

    Article  ADS  CAS  Google Scholar 

  13. Chamberlain, J. R. et al. Science 303, 1198–1201 (2004).

    Article  ADS  CAS  Google Scholar 

  14. Hwang, W. S. et al. Science 303, 1669–1674 (2004).

    Article  ADS  CAS  Google Scholar 

Download references

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Zaret, K. Self-help for insulin cells. Nature 429, 30–31 (2004). https://doi.org/10.1038/429030a

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