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Cancer

Kip moving

The p27Kip1 protein inhibits cell proliferation, helping to prevent tumours developing. We now know that it also affects cell migration, by regulating Rho proteins. Does this function influence tumour progression?

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Figure 1: Dual function of a tumour suppressor.

References

  1. Besson, A., Gurian-West, M., Schmidt, A., Hall, A. & Roberts, J. M. Genes Dev. 18, 862–876 (2004).

    CAS  Article  Google Scholar 

  2. Philipp-Staheli, J., Payne, S. R. & Kemp, C. J. Exp. Cell Res. 264, 148–168 (2001).

    CAS  Article  Google Scholar 

  3. Philipp-Staheli, J. et al. Cancer Cell 1, 355–368 (2002).

    Article  Google Scholar 

  4. Slingerland, J. & Pagano, M. J. Cell. Physiol. 183, 10–17 (2000).

    CAS  Article  Google Scholar 

  5. McAllister, S. S., Becker-Hapak, M., Pintucci, G., Pagano, M. & Dowdy, S. F. Mol. Cell. Biol. 23, 216–228 (2003).

    CAS  Article  Google Scholar 

  6. Ridley, A. J. et al. Science 302, 1704–1709 (2003).

    ADS  CAS  Article  Google Scholar 

  7. Malliri, A. & Collard, J. G. Curr. Opin. Cell Biol. 15, 583–589 (2003).

    CAS  Article  Google Scholar 

  8. Friedl, P. & Wolf, K. Nature Rev. Cancer 3, 362–374 (2003).

    CAS  Article  Google Scholar 

  9. Sahai, E. & Marshall, C. J. Nature Cell Biol. 5, 711–719 (2003).

    CAS  Article  Google Scholar 

  10. Goukassian, D. et al. FASEB J. 15, 1877–1885 (2001).

    CAS  Article  Google Scholar 

  11. Kouvaraki, M. et al. Cancer 94, 2454–2465 (2002).

    CAS  Article  Google Scholar 

  12. Saez, A. et al. Br. J. Cancer 80, 1427–1434 (1999).

    CAS  Article  Google Scholar 

  13. Boettner, B. & van Aelst, L. Gene 286, 155–174 (2002).

    CAS  Article  Google Scholar 

Download references

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Collard, J. Kip moving. Nature 428, 705–708 (2004). https://doi.org/10.1038/428705a

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  • DOI: https://doi.org/10.1038/428705a

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