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Evolutionary biology

Lost and found

Can we ever hope to pin down the genetic changes that underlie the big steps in evolution? Possibly so, if a study of the variation in the pelvic fins of sticklebacks is anything to go by.

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Figure 1: Sticklebacks under scrutiny.


Figure 2: Evolution in action: a genetic basis.


  1. Darwin, C. On The Origin of Species (Murray, London, 1859).

    Google Scholar 

  2. Shapiro, M. D. et al. Nature 428, 717–723 (2004).

    ADS  CAS  Article  Google Scholar 

  3. Morse, E. S. Ann. Lyceum Nat. Hist. NY 10, 141–158 (1872).

    Article  Google Scholar 

  4. Lande, R. Evolution 32, 73–92 (1978).

    Article  Google Scholar 

  5. Lanctôt, C. et al. Development 126, 1805–1810 (1999).

    PubMed  Google Scholar 

  6. Szeto, D. P. et al. Genes Dev. 13, 484–494 (1999).

    CAS  Article  Google Scholar 

  7. Marcil, A. et al. Development 130, 45–55 (2003).

    CAS  Article  Google Scholar 

  8. Carroll, S. B. Cell 101, 570–580 (2000).

    Article  Google Scholar 

  9. Levine, M. & Tjian, R. Nature 424, 147–151 (2003).

    ADS  CAS  Article  Google Scholar 

  10. Mundy, N. I. et al. Science 303, 1870–1873 (2004).

    ADS  CAS  Article  Google Scholar 

  11. Colosimo, P. F. et al. PLoS Biol. doi:10.1371/journal.pbio.0020109

  12. Gould, S. J. The Structure of Evolutionary Theory (Harvard Univ. Press, Cambridge, MA, 2002).

    Google Scholar 

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Shubin, N., Dahn, R. Lost and found. Nature 428, 703–704 (2004).

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