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Molecular biology

Case of mistaken identity

An enzyme involved at grass-roots level in assembling genes for receptors that are essential in fighting infection has now been fingered as a suspect in certain cancers — proof that mistakes can be costly.

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Figure 1: Aberrant V(D)J recombination and translocation.

References

  1. Roth, D. B. Nature Rev. Immunol. 3, 656–666 (2003).

    CAS  Article  Google Scholar 

  2. Mills, K. D., Ferguson, D. O. & Alt, F. W. Immunol. Rev. 194, 77–95 (2003).

    CAS  Article  Google Scholar 

  3. Raghavan, S. C., Swanson, P. C., Wu, X., Hsieh, C.-L. & Lieber, M. R. Nature 428, 88–93 (2004).

    ADS  CAS  Article  Google Scholar 

  4. Fugmann, S. D., Lee, A. I., Shockett, P. E., Villey, I. J. & Schatz, D. G. Annu. Rev. Immunol. 18, 495–527 (2000).

    CAS  Article  Google Scholar 

  5. McGuire, E. A. et al. Mol. Cell. Biol. 9, 2124–2132 (1989).

    CAS  Article  Google Scholar 

  6. Tycko, B. & Sklar, J. Cancer Cells 2, 1–8 (1990).

    CAS  PubMed  Google Scholar 

  7. Croce, C. M. & Nowell, P. C. Adv. Immunol. 38, 245–274 (1986).

    CAS  Article  Google Scholar 

  8. Elliott, B. & Jasin, M. Cell. Mol. Life Sci. 59, 373–385 (2002).

    CAS  Article  Google Scholar 

  9. Marculescu, R., Le, T., Simon, P., Jaeger, U. & Nadel, B. J. Exp. Med. 195, 85–98 (2002).

    CAS  Article  Google Scholar 

  10. Chaudhuri, J. et al. Nature 422, 726–730 (2003).

    ADS  CAS  Article  Google Scholar 

Download references

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Bassing, C., Alt, F. Case of mistaken identity. Nature 428, 29–31 (2004). https://doi.org/10.1038/428029a

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