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Cell biology

A cellular choreographer

Specialized cells that form barriers such as those of the intestine adopt a distinct asymmetry. One particular protein may be a prime mover in bringing about such cellular organization.

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Figure 1: Structure of the intestine and epithelial polarity.
Figure 2: LKB1 and cell polarization.

References

  1. Baas, A. F. et al. Cell 116, 457–466 (2004).

    Article  CAS  PubMed  Google Scholar 

  2. Boudeau, J., Sapkota, G. & Alessi, D. R. FEBS Lett. 546, 159–165 (2003).

    Article  CAS  PubMed  Google Scholar 

  3. Jenne, D. E. et al. Nature Genet. 18, 38–43 (1998).

    Article  CAS  PubMed  Google Scholar 

  4. Bardeesy, N. et al. Nature 419, 162–167 (2002).

    Article  ADS  CAS  PubMed  Google Scholar 

  5. Karuman, P. et al. Mol. Cell 7, 1307–1319 (2001).

    Article  CAS  PubMed  Google Scholar 

  6. Watts, J. L., Morton, D. G., Bestman, J. & Kemphues, K. J. Development 127, 1467–1475 (2000).

    CAS  PubMed  Google Scholar 

  7. Martin, S. G. & St Johnston, D. Nature 421, 379–384 (2003).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Baas, A. F. et al. EMBO J. 22, 3062–3072 (2003).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Vega-Salas, D. E., Salas, P. J. & Rodriguez-Boulan, E. J. Cell Biol. 107, 1717–1728 (1988).

    Article  CAS  PubMed  Google Scholar 

  10. Streuli, C. H., Bailey, N. & Bissell, M. J. J. Cell Biol. 115, 1383–1395 (1991).

    Article  CAS  PubMed  Google Scholar 

  11. Friederich, E., Huet, C., Arpin, M. & Louvard, D. Cell 59, 461–475 (1989).

    Article  CAS  PubMed  Google Scholar 

  12. Sapkota, G. P. et al. J. Biol. Chem. 276, 19469–19482 (2001).

    Article  CAS  PubMed  Google Scholar 

Download references

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Nelson, W. A cellular choreographer. Nature 428, 28–29 (2004). https://doi.org/10.1038/428028a

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