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Changes in grey matter induced by training

Newly honed juggling skills show up as a transient feature on a brain-imaging scan.


Does the structure of an adult human brain alter in response to environmental demands1,2? Here we use whole-brain magnetic-resonance imaging to visualize learning-induced plasticity in the brains of volunteers who have learned to juggle. We find that these individuals show a transient and selective structural change in brain areas that are associated with the processing and storage of complex visual motion. This discovery of a stimulus-dependent alteration in the brain's macroscopic structure contradicts the traditionally held view that cortical plasticity is associated with functional rather than anatomical changes.

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  1. 1

    Draganski, B. et al. Nature Med. 8, 1186–1188 (2002).

  2. 2

    Maguire, E. A. et al. Proc. Natl Acad. Sci. USA 97, 4398–4403 (2000).

  3. 3

    Kempermann, G., Gast, D. & Gage, F. H. Ann. Neurol. 52, 135–143 (2002).

  4. 4

    Trachtenberg, J. T. et al. Nature 420, 788–794 (2002).

  5. 5

    Grutzendler, J., Kasthuri, N. & Gan, W. B. Nature 420, 812–816 (2002).

  6. 6

    Ashburner, J. & Friston, K. J. Neuroimage 11, 805–821 (2000).

  7. 7

    Good, C. D. et al. Neuroimage 17, 29–46 (2002).

  8. 8

    Bisley, J. W. & Pasternak, T. Cereb. Cortex 10, 1053–1065 (2000).

  9. 9

    Sereno, M. I., Pitzalis, S. & Martinez, A. Science 294, 1350–1354 (2001).

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Correspondence to Arne May.

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The authors declare no competing financial interests.

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Figure 1: Transient changes in brain structure induced while learning to juggle.


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