Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Taking apart a cancer protein

Generation of a particular 'fusion' protein is characteristic of one type of leukaemia. But is it in fact the cleavage of this protein into smaller parts that is important? Provocative new findings suggest that it is.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Get just this article for as long as you need it


Prices may be subject to local taxes which are calculated during checkout

Figure 1: Hypothetical role of the PML–RARα fusion protein in acute promyelocytic leukaemia (APL).


  1. Melnick, A. & Licht, J. D. Blood 93, 3167–3215 (1999).

    CAS  PubMed  Google Scholar 

  2. Lane, A. A. & Ley, T. J. Cell 115, 305–318 (2003).

    Article  CAS  PubMed  Google Scholar 

  3. Reya, T., Morrison, S. J., Clarke, M. F. & Weissman, I. L. Nature 414, 105–111 (2001).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Piazza, F., Gurrieri, C. & Pandolfi, P. P. Oncogene 20, 7216–7222 (2001).

    Article  CAS  PubMed  Google Scholar 

  5. Hansen, L. A. et al. Cancer Res. 63, 5257–5265 (2003).

    CAS  PubMed  Google Scholar 

  6. David, G., Terris, B., Marchio, A., Lavau, C. & Dejean, A. Oncogene 14, 1547–1554 (1997).

    Article  CAS  PubMed  Google Scholar 

  7. Lin, R. J., Sternsdorf, T., Tini, M. & Evans R. M. Oncogene 20, 7204–7215 (2001).

    Article  CAS  PubMed  Google Scholar 

  8. Kastner, P. & Chan, S. Oncogene 20, 7178–7185 (2001).

    Article  CAS  PubMed  Google Scholar 

  9. Salomoni, P. & Pandolfi, P. P. Cell 108, 165–170 (2002).

    Article  CAS  PubMed  Google Scholar 

  10. Minucci, S. et al. Blood 100, 2989–2995 (2002).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Pier Paolo Pandolfi.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Paolo Scaglioni, P., Paolo Pandolfi, P. Taking apart a cancer protein. Nature 426, 512–513 (2003).

Download citation

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing