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Taking apart a cancer protein

Generation of a particular 'fusion' protein is characteristic of one type of leukaemia. But is it in fact the cleavage of this protein into smaller parts that is important? Provocative new findings suggest that it is.

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Figure 1: Hypothetical role of the PML–RARα fusion protein in acute promyelocytic leukaemia (APL).

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Correspondence to Pier Paolo Pandolfi.

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Paolo Scaglioni, P., Paolo Pandolfi, P. Taking apart a cancer protein. Nature 426, 512–513 (2003). https://doi.org/10.1038/426512a

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