Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Stem cells

Interactive niches

The microenvironment, or niche, in which stem cells reside controls their renewal and maturation. The niche that regulates blood-forming stem cells in adult animals has eluded researchers — until now.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Birth control for stem cells.

References

  1. Kiger, A. A., Jones, D. L., Schulz, C., Rogers, M. B. & Fuller, M. T. Science 294, 2542–2545 (2001).

    ADS  CAS  Article  PubMed  Google Scholar 

  2. Spradling, A., Drummond-Barbosa, D. & Kai, T. Nature 414, 98–104 (2001).

    ADS  CAS  Article  PubMed  Google Scholar 

  3. Kopan, R. et al. Dev. Biol. 242, 44–57 (2002).

    CAS  Article  PubMed  Google Scholar 

  4. Marshman, E., Booth, C. & Potten, C. S. BioEssays 24, 91–98 (2002).

    Article  PubMed  Google Scholar 

  5. Nishimura, E. K. et al. Nature 416, 854–860 (2002).

    ADS  CAS  Article  PubMed  Google Scholar 

  6. Alonso, L. & Fuchs, E. Proc. Natl Acad. Sci. USA 100, 11830–11835 (2003).

    ADS  CAS  Article  PubMed  PubMed Central  Google Scholar 

  7. Zhang, J. et al. Nature 425, 836–841 (2003).

    ADS  CAS  Article  PubMed  Google Scholar 

  8. Calvi, L. M. et al. Nature 425, 841–846 (2003).

    ADS  CAS  Article  PubMed  Google Scholar 

  9. Lord, B. I. Int. J. Cell Cloning 8, 317–331 (1990).

    CAS  Article  PubMed  Google Scholar 

  10. Nilsson, S. K., Johnston, H. M. & Coverdale, J. A. Blood 97, 2293–2299 (2001).

    CAS  Article  PubMed  Google Scholar 

  11. Dexter, T. M., Allen, T. D. & Lajtha, L. G. J. Cell. Physiol. 91, 335–344 (1977).

    CAS  Article  PubMed  Google Scholar 

  12. Moore, K. A. Blood 89, 4337–4347 (1997).

    CAS  PubMed  Google Scholar 

  13. Taichman, R. S. & Emerson, S. G. Stem Cells 16, 7–15 (1998).

    CAS  Article  PubMed  Google Scholar 

  14. Reya, T. et al. Nature 423, 409–414 (2003).

    ADS  CAS  Article  PubMed  Google Scholar 

  15. Chi, J.-T. et al. Proc. Natl Acad. Sci. USA 100, 10623–10628 (2003).

    ADS  CAS  Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ihor R. Lemischka.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lemischka, I., Moore, K. Interactive niches. Nature 425, 778–779 (2003). https://doi.org/10.1038/425778a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/425778a

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing