At synapses, nerve cells release neurotransmitters, which affect other nerve cells or muscles. Studies of how muscles in turn influence neurotransmitter release hint at how synapses adapt to changes in use.
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Salinas, P. Backchat at the synapse. Nature 425, 464–467 (2003). https://doi.org/10.1038/425464a
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DOI: https://doi.org/10.1038/425464a