Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Immunology

Dangerous liaisons

Alerting the immune system to invading microorganisms is essential for effective immunity. Uric acid released by damaged cells is a danger signal that is able to notify immune cells of microbial attack.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Strangers and danger.

References

  1. Shi, Y., Evans, J. E. & Rock, K. L. Nature 425, 516–521 (2003).

    ADS  CAS  Article  Google Scholar 

  2. Janeway, C. A. Jr Cold Spring Harb. Symp. Quant. Biol. 54, 1–13 (1989).

    CAS  Article  Google Scholar 

  3. Medzhitov, R. & Janeway, C. A. Jr Science 296, 298–300 (2002).

    ADS  CAS  Article  Google Scholar 

  4. Takeda, K., Kaisho, T. & Akira, S. Annu. Rev. Immunol. 21, 335–376 (2003).

    CAS  Article  Google Scholar 

  5. Matzinger, P. Annu. Rev. Immunol. 12, 991–1045 (1994).

    CAS  Article  Google Scholar 

  6. Matzinger, P. Science 296, 301–305 (2002).

    ADS  CAS  Article  Google Scholar 

  7. Srivastava, P. Nature Rev. Immunol. 2, 185–194 (2002).

    CAS  Article  Google Scholar 

  8. Sauter, B. et al. J. Exp. Med. 191, 423–434 (2000).

    CAS  Article  Google Scholar 

  9. Gallucci, S., Lolkema, M. & Matzinger, P. Nature Med. 5, 1249–1255 (1999).

    CAS  Article  Google Scholar 

  10. Shi, Y., Zheng, W. & Rock, K. L. Proc. Natl Acad. Sci. USA 97, 14590–14595 (2000).

    ADS  CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Heath, W., Carbone, F. Dangerous liaisons. Nature 425, 460–461 (2003). https://doi.org/10.1038/425460a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/425460a

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing