It has long been proposed that stem cells function by dividing to generate an identical daughter cell and a cell that becomes more specialized. New work illustrates such asymmetric division and its molecular basis.
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References
Yamashita, Y. M., Jones, D. L. & Fuller, M. T. Science 301, 1547–1550 (2003).
Jan, Y.-N. & Jan, L. Y. Nature Rev. Neurosci. 2, 772–779 (2001).
Lin, H. Nature Rev. Genet. 3, 931–940 (2002).
Deng, W. & Lin, H. Dev. Biol. 189, 79–94 (1997).
Hardy, R. W., Tokuyasu, K. T., Lindsley, D. L. & Garavito, M. J. Ultrastruct. Res. 69, 180–190 (1979).
Megraw, T. L., Kao, L. R. & Kaufman, T. C. Curr. Biol. 11, 116–120 (2001).
Song, X., Zhu, C. H., Doan, C. & Xie, T. Science 296, 1855–1857 (2002).
McCartney, B. M. et al. Nature Cell Biol. 3, 933–938 (2001).
Lu, B. et al. Nature 409, 522–525 (2001).
Watt, F. M. & Hogan, B. L. M. Science 287, 1427–1430 (2000).
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Lin, H. To be and not to be. Nature 425, 353–355 (2003). https://doi.org/10.1038/425353a
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DOI: https://doi.org/10.1038/425353a
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