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Cardiovascular biology

Signalling silenced

The mechanism by which the TIMP-2 protein inhibits blood-vessel formation has been uncovered — and it is not as expected. The finding has implications for treating a cancer by cutting off its blood supply.

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Figure 1: Blocking blood-vessel growth: how TIMP-2 does it.


  1. Overall, C. M. & Lopez-Otin, C. Nature Rev. Cancer 2, 657–672 (2002).

    Article  CAS  Google Scholar 

  2. Brinckerhoff, C. E. & Matrisian, L. M. Nature Rev. Mol. Cell Biol. 3, 207–214 (2002).

    Article  CAS  Google Scholar 

  3. Egeblad, M. & Werb, Z. Nature Rev. Cancer 2, 161–174 (2002).

    CAS  Google Scholar 

  4. Coussens, L. M., Fingleton, B. & Matrisian, L. M. Science 295, 2387–2392 (2002).

    Article  ADS  CAS  Google Scholar 

  5. Seo, D. W. et al. Cell 114, 171–180 (2003).

    Article  CAS  Google Scholar 

  6. McCarthy, M. Lancet 361, 1959 (2003).

    Article  Google Scholar 

  7. Murphy, A. N., Unsworth, E. J. & Stetler-Stevenson, W. G. J. Cell Physiol. 157, 351–358 (1993).

    Article  CAS  Google Scholar 

  8. Qi, J. H. et al. Nature Med. 9, 407–415 (2003).

    Article  CAS  Google Scholar 

  9. Stetler-Stevenson, W. G., Krutzsch, H. C. & Liotta, L. A. Matrix 1 (Suppl.), 299–306 (1992).

    CAS  PubMed  Google Scholar 

  10. Valente, P. et al. Int. J. Cancer 75, 246–253 (1998).

    Article  CAS  Google Scholar 

  11. Hajitou, A. et al. Cancer Res. 61, 3450–3457 (2001).

    CAS  PubMed  Google Scholar 

  12. Fernandez, C. A., Butterfield, C., Jackson, G. & Moses, M. A. J. Biol. Chem. published online 4 August 2003 (doi:10.1074/jbc.M306176200).

  13. Schlessinger, J. Cell 103, 211–225 (2000).

    Article  CAS  Google Scholar 

  14. Ostman, A. & Bohmer, F. D. Trends Cell Biol. 11, 258–266 (2001).

    Article  CAS  Google Scholar 

  15. Wang, Z., Juttermann, R. & Soloway, P. D. J. Biol. Chem. 275, 26411–26415 (2000).

    Article  CAS  Google Scholar 

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Correspondence to Peter Carmeliet.

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Conway, E., Carmeliet, P. Signalling silenced. Nature 425, 139–140 (2003).

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