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Developmental biology

Hotspots for evolution

Two studies of fruitflies suggest that although development relies on a diverse toolkit of genes, the evolution of physical characteristics might be powered by variation in just a few of these tools.

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Figure 1: Shavenbabies are hairy.


  1. Stern, D. L. Evolution 54, 1079–1091 (2000).

    CAS  Article  Google Scholar 

  2. Tautz, D. & Schmid, J. Phil. Trans. R. Soc. Lond. B 353, 231–240 (1998).

    CAS  Article  Google Scholar 

  3. Sucena, E., Delon, I., Jones, I., Payre, F. & Stern, D. L. Nature 424, 935–938 (2003).

    ADS  CAS  Article  Google Scholar 

  4. Gompel, N. & Carroll, S. B. Nature 424, 931–935 (2003).

    ADS  CAS  Article  Google Scholar 

  5. Struhl, G. A Nature 292, 635–638 (1981).

    ADS  CAS  Article  Google Scholar 

  6. Richardson, M. K. & Chipman, A. D. J. Exp. Zool. 296B, 8–22 (2003).

    Article  Google Scholar 

  7. Bokor, P. & DiNardo, S. Development 122, 1083–1092 (1996).

    CAS  PubMed  Google Scholar 

  8. Hatini,V. et al. Genes Dev. 14, 1364–1376 (2000).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Beldade, P. & Brakefield, P. M. Nature Rev. Genet. 3, 442–452 (2002).

    CAS  Article  Google Scholar 

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Correspondence to Michael K. Richardson or Paul M. Brakefield.

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Richardson, M., Brakefield, P. Hotspots for evolution. Nature 424, 894–895 (2003).

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