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Cell biology

Tumour jailbreak

New work shows that a cage-like matrix of protein fibres around cells can inhibit the growth of tumours. But cancer cells producing the enzyme MT1-MMP can cleave this matrix and proliferate freely.

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Figure 1: Tumour cells: prisoners and escapees.


  1. Hotary, K. B. et al. Cell 114, 33–45 (2003).

  2. Frisch, S. M. & Screaton, R. A. Curr. Opin. Cell Biol. 13, 555–562 (2001).

    Article  CAS  Google Scholar 

  3. Dvorak, H. F., Senger, D. R. & Dvorak, A. M. Cancer Metastasis Rev. 2, 41–73 (1983).

    Article  CAS  Google Scholar 

  4. Coussens, L. M., Fingleton, B. & Matrisian, L. M. Science 295, 2387–2392 (2002).

    Article  ADS  CAS  Google Scholar 

  5. Bissell, M. J. & Radisky, D. Nature Rev. Cancer 1, 46–54 (2001).

    Article  CAS  Google Scholar 

  6. Cukierman, E., Pankov, R., Stevens, D. R. & Yamada, K. M. Science 294, 1708–1712 (2001).

    Article  ADS  CAS  Google Scholar 

  7. Walpita, D. & Hay, E. Nature Rev. Mol. Cell Biol. 3, 137–141 (2002).

    Article  CAS  Google Scholar 

  8. Grinnell, F. Trends Cell Biol. 13, 264–269 (2003).

    Article  CAS  Google Scholar 

  9. Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M. & Ingber, D. E. Science 276, 1425–1428 (1997).

    Article  CAS  Google Scholar 

  10. Wolf, K. et al. J. Cell Biol. 160, 267–277 (2003).

    Article  CAS  Google Scholar 

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Yamada, K. Tumour jailbreak. Nature 424, 889–890 (2003).

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