Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cell biology

Tumour jailbreak

New work shows that a cage-like matrix of protein fibres around cells can inhibit the growth of tumours. But cancer cells producing the enzyme MT1-MMP can cleave this matrix and proliferate freely.

Your institute does not have access to this article

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Tumour cells: prisoners and escapees.


  1. Hotary, K. B. et al. Cell 114, 33–45 (2003).

  2. Frisch, S. M. & Screaton, R. A. Curr. Opin. Cell Biol. 13, 555–562 (2001).

    CAS  Article  Google Scholar 

  3. Dvorak, H. F., Senger, D. R. & Dvorak, A. M. Cancer Metastasis Rev. 2, 41–73 (1983).

    CAS  Article  Google Scholar 

  4. Coussens, L. M., Fingleton, B. & Matrisian, L. M. Science 295, 2387–2392 (2002).

    ADS  CAS  Article  Google Scholar 

  5. Bissell, M. J. & Radisky, D. Nature Rev. Cancer 1, 46–54 (2001).

    CAS  Article  Google Scholar 

  6. Cukierman, E., Pankov, R., Stevens, D. R. & Yamada, K. M. Science 294, 1708–1712 (2001).

    ADS  CAS  Article  Google Scholar 

  7. Walpita, D. & Hay, E. Nature Rev. Mol. Cell Biol. 3, 137–141 (2002).

    CAS  Article  Google Scholar 

  8. Grinnell, F. Trends Cell Biol. 13, 264–269 (2003).

    CAS  Article  Google Scholar 

  9. Chen, C. S., Mrksich, M., Huang, S., Whitesides, G. M. & Ingber, D. E. Science 276, 1425–1428 (1997).

    CAS  Article  Google Scholar 

  10. Wolf, K. et al. J. Cell Biol. 160, 267–277 (2003).

    CAS  Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Rights and permissions

Reprints and Permissions

About this article

Cite this article

Yamada, K. Tumour jailbreak. Nature 424, 889–890 (2003).

Download citation

  • Issue Date:

  • DOI:


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing