The immune response to microbes involves a well-known signalling cascade — but this doesn't control all aspects of anti-pathogen warfare. A second cascade, involving a new 'adaptor' protein, helps fill the gap.
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References
Janeway, C. A. Jr & Medzhitov, R. Annu. Rev. Immunol. 20, 197–216 (2002).
Takeda, K. & Akira, S. Cell. Microbiol. 5, 143–153 (2003).
Hoebe, K. et al. Nature 424, 743–748 (2003).
Yamamoto, M. et al. Science 301, 640–643 (2003).
Alexopoulou, L., Holt, A. C., Medzhitov, R. & Flavell, R. A. Nature 413, 732–738 (2001).
Poltorak, A. et al. Science 282, 2085–2088 (1998).
Yamamoto, M. et al. J. Immunol. 169, 6668–6672 (2002).
Oshiumi, H. et al. Nature Immunol. 4, 161–167 (2003).
Yamamoto, M. et al. Nature 420, 324–329 (2002).
Horng, T., Barton, G. M., Flavell, R. A. & Medzhitov, R. Nature 420, 329–333 (2002).
O'Neill, L. A. J., Fitzgerald, K. A. & Bowie, A. G. Trends Immunol. 24, 286–289 (2003).
Sharma, S. et al. Science 300, 1148–1151 (2003).
Fitzgerald, K. A. et al. Nature Immunol. 4, 491–496 (2003).
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Yeh, WC., Chen, NJ. Another toll road. Nature 424, 736–737 (2003). https://doi.org/10.1038/424736a
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DOI: https://doi.org/10.1038/424736a
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