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Cell biology

Moving inside membranes

The mechanism that inserts proteins into the membranes of cellular organelles was thought to be well understood. But studies in yeast reveal that this process is sometimes more complicated than had been suspected.

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Figure 1: Sorting and assembly pathways of mitochondrial precursor proteins.


  1. Wiedemann, V. et al. Nature 424, 565–571 (2003).

    ADS  CAS  Article  Google Scholar 

  2. Pfanner, N. & Geissler, A. Mol. Cell Biol. 2, 339–349 (2001).

    CAS  Google Scholar 

  3. Model, C. et al. Nature Struct. Biol. 8, 361–370 (2001).

    ADS  CAS  Article  Google Scholar 

  4. Gratzer, S. et al. J. Cell Biol. 129, 25–34 (1995).

    CAS  Article  Google Scholar 

  5. Ryan, M. T., Müller, H. & Pfanner, N. J. Biol. Chem. 274, 20619–20627 (1999).

    CAS  Article  Google Scholar 

  6. Johnson, A. E. & van Waes, M. A. Annu. Rev. Cell Dev. Biol. 15, 799–842 (1999).

    Article  Google Scholar 

  7. Jarvis, P. & Soll, J. Biochim. Biophys. Acta 1541, 64–79 (2001).

    CAS  Article  Google Scholar 

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Mihara, K. Moving inside membranes. Nature 424, 505–506 (2003).

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