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A powerful arm of the cellular defence against microbial invaders has been characterized. APOBEC3G, a protein that can fight off HIV, works by introducing 'typographical errors' during viral replication.

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Figure 1: Editing HIV: how the cellular APOBEC3G protein might inhibit HIV replication5,6,7,10.

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Correspondence to Wesley I. Sundquist.

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Gu, Y., Sundquist, W. Good to CU. Nature 424, 21–22 (2003). https://doi.org/10.1038/424021a

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