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Neurobiology

Synapses unplugged

At the junctions between two neurons, the machinery that releases neurotransmitter from one cell must lie near calcium channels and align with detectors in the receiving cell. We now have a better idea how this occurs.

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Figure 1: A neurexin-based adhesion complex in synapses.

References

  1. Missler, M. et al. Nature 423, 939–948 (2003).

    Article  ADS  CAS  Google Scholar 

  2. Katz, B. & Miledi, R. Proc. R. Soc. Lond. B Biol. Sci. 161, 496–503 (1965).

    Article  ADS  CAS  Google Scholar 

  3. Smith, S. J. & Augustine, G. J. Trends Neurosci. 11, 458–464 (1988).

    Article  CAS  Google Scholar 

  4. Atlas, D. J. Neurochem. 77, 972–985 (2001).

    Article  CAS  Google Scholar 

  5. Ushkaryov, Y. A., Petrenko, A. G., Geppert, M. & Südhof, T. C. Science 257, 50–56 (1992).

    Article  ADS  CAS  Google Scholar 

  6. Ulrich, B., Ushkaryov, Y. A. & Südhof, T. C. Neuron 14, 497–507 (1995).

    Article  Google Scholar 

  7. Ichtchenko, K. Y. et al. Cell 81, 435–443 (1995).

    Article  CAS  Google Scholar 

  8. Sugita, S. et al. J. Cell Biol. 154, 435–445 (2001).

    Article  CAS  Google Scholar 

  9. Scheiffele, P., Fan, J., Choih, J., Fetter, R. & Serafini, T. Cell 101, 657–669 (2000).

    Article  CAS  Google Scholar 

  10. Garner, C. C., Nash, J. & Huganir, R. L. Trends Cell Biol. 10, 274–280 (2000).

    Article  CAS  Google Scholar 

Download references

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Correspondence to J. Troy Littleton or Morgan Sheng.

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Littleton, J., Sheng, M. Synapses unplugged. Nature 423, 931–932 (2003). https://doi.org/10.1038/423931a

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