Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Taking the measure

Telomeres — the tips of chromosomes — need to be preserved, and this involves replenishing telomeric DNA when it has been eroded. But telomeres must not become too long, and one aspect of length control is now revealed.

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Model for telomere length control.


  1. Loayza, D. & de Lange, T. Nature 423, 1013–1018 (2003).

    Article  CAS  ADS  Google Scholar 

  2. Colgin, L. M., Baran, K., Baumann, P., Cech, T. R. & Reddel, R. R. Curr. Biol. 13, 942–946 (2003).

    Article  CAS  Google Scholar 

  3. Lee, H.-W. et al. Nature 392, 569–574 (1998).

    Article  CAS  ADS  Google Scholar 

  4. Damm, K. et al. EMBO J. 20, 6958–6968 (2001).

    Article  CAS  Google Scholar 

  5. Evans, S. K. & Lundblad, V. Science 286, 117–120 (1999).

    Article  CAS  Google Scholar 

  6. Marcand, S., Gilson, E. & Shore, D. Science 275, 986–990 (1997).

    Article  CAS  Google Scholar 

  7. Smogorzewska, A. et al. Mol. Cell. Biol. 20, 1659–1668 (2000).

    Article  CAS  Google Scholar 

  8. Baumann, P. & Cech, T. R. Science 297, 1171–1175 (2001).

    Article  ADS  Google Scholar 

  9. Mitton-Fry, R. M., Anderson, E. M., Hughes, T. R., Lundblad, V. & Wuttke, D. S. Science 296, 145–147 (2002).

    Article  CAS  ADS  Google Scholar 

  10. Peersen, O. B., Ruggles, J. A. & Schultz, S. C. Nature Struct. Biol. 9, 182–187 (2002).

    CAS  PubMed  Google Scholar 

  11. Chandra, A., Hughes, T. R., Nugent, C. I. & Lundblad, V. Genes Dev. 15, 404–414 (2001).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Vicki Lundblad.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Lundblad, V. Taking the measure. Nature 423, 926–927 (2003).

Download citation

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing