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The double puzzle of diabetes

Why is the prevalence of type 2 diabetes mellitus now exploding in most populations, but not in Europeans? The genetic and evolutionary consequences of geographical differences in food history may provide the answer.

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Figure 1: Age-standardized prevalence of type 2 diabetes mellitus.


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It is a pleasure to acknowledge my debt for fruitful discussions about diabetes with Paul Zimmet and Jerome Rotter, and about European food history with Jack Goldstone and William Jordan.

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Correspondence to Jared Diamond.

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Diamond, J. The double puzzle of diabetes. Nature 423, 599–602 (2003).

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