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Signal transduction

A regulator branches out

The cellular signalling pathway that leads to activation of the NF-κB protein has been studied for many years, and one might think that there's little left to learn. But it still has some surprises in store.

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Figure 1: The classical NF-κB cascade, the alternative — and a new twist.

References

  1. Yamamoto, Y., Verma, U. N., Prajapati, S., Kwak, Y.-T. & Gaynor, R. B. Nature 423, 655–659 (2003).

    ADS  CAS  Article  Google Scholar 

  2. Anest, V. et al. Nature 423, 659–663 (2003).

    ADS  CAS  Article  Google Scholar 

  3. Ghosh, S. & Karin, M. Cell 109, S81–S96 (2002).

    CAS  Article  Google Scholar 

  4. Strahl, B. D. & Allis, C. D. Nature 403, 41–45 (2000).

    ADS  CAS  Article  Google Scholar 

  5. Cheung, P., Allis, C. D. & Sassone-Corsi, P. Cell 103, 263–271 (2000).

    CAS  Article  Google Scholar 

  6. Hu, Y. et al. Nature 410, 710–714 (2001).

    ADS  CAS  Article  Google Scholar 

  7. Li, X. et al. J. Biol. Chem. 277, 45129–45140 (2002).

    CAS  Article  Google Scholar 

  8. Li, Q. T. et al. Genes Dev. 13, 1322–1328 (1999).

    CAS  Article  Google Scholar 

  9. Saccani, S., Pantano, S. & Natoli, G. J. Exp. Med. 193, 1351–1359 (2001).

    CAS  Article  Google Scholar 

  10. Zhong, H., May, M. J., Jimi, E. & Ghosh, S. Mol. Cell 9, 625–636 (2002).

    CAS  Article  Google Scholar 

  11. Cao, Y. et al. Cell 107, 763–775 (2001).

    CAS  Article  Google Scholar 

Download references

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Correspondence to Alain Israël.

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Israël, A. A regulator branches out. Nature 423, 596–597 (2003). https://doi.org/10.1038/423596a

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